Rabbi Moshe Biderman, the second Rebbe of the Lelov Chassidic dynasty, was born in 5537 (1776) in Lelów, Poland, into deep poverty. His father, Rabbi David of Lelov, founder of the dynasty, was one of the greatest disciples of the Chozeh of Lublin; his mother was Chana.

From his youth he absorbed Torah and Chassidut from his father and from the Chozeh of Lublin. After his first wife passed away, he married Rivka Rochel, daughter of the "Holy Jew," Rabbi Yaakov Yitzchak of Peshischa. After the passing of his father and father-in-law, he and his friend Rabbi Yisrael Yitzchak of Vurka became disciples of Rabbi Simcha Bunim of Peshischa. Like his father, he was renowned for his great love of every Jew.

The sources differ on his role as a leader: one states that he succeeded his father as Rebbe of Lelov as early as 5574 (1814); another describes a hidden tzaddik who long refused any position and only in 1847 agreed to become Rebbe in Przedborz. In any case he served as rabbi of Przedborz until he left for the Land of Israel, for which he yearned all his life. Among his disciples was Rabbi Shlomo of Radomsk, author of Tiferet Shlomo, who accompanied him through the towns where he raised funds for the journey.

He emigrated with a large part of his family. Landing in Acre, he visited Safed and Tiberias; in Safed, Rabbi Shmuel Heller offered him the city's rabbinate, but he declined and continued to Jerusalem, intending to pray at the Western Wall for the Redemption. He fell ill on arrival, and when his sons tried to carry him there on his bed, they were driven back with stones.

He passed away on 13 Tevet 5611 (December 18, 1850), a little over two months after arriving, and was buried on the Mount of Olives near the tomb of the prophet Zechariah. His son Rabbi Elazar Mendel succeeded him in Jerusalem.