Rabbi Eliezer Supino (Sufino), son of Rabbi Yaakov Supino, was born in Livorno around 1685. In his youth he studied in Livorno under Rabbi Shmuel di Paz. He lived for a time in Siena, and in 1732 (5492) was appointed rabbi of the city of Pisa.

He was the central figure of the “Shabbat of the bridegroom controversy”. Around 1735 in Pisa, when a bridegroom was called up to the Torah as one of the seven, the cantor kept silent because he saw that the city's rabbi, Rabbi Eliezer, kept silent. Rabbi David Meldola ruled that this was an error, backed by his brother-in-law Rabbi Raphael Meldola; Rabbi Eliezer sharply disputed their view and ruled in favour of the community's custom.

After the Meldolas' responsa were printed in Mayim Rabbim, he wrote a pamphlet in reply and sent it to be printed in Amsterdam. Printing, probably delayed by the author's poverty, took three years. Before the copies reached Livorno they were seized by the rabbinical court, on the ruling of Rabbi Aryeh Leib ben Shaul, grandson of the Chacham Tzvi, and later burned. Before leaving Italy, Rabbi Eliezer reconciled with both rabbis; according to Rabbi David Meldola, they parted “with great love”.

He moved to the Land of Israel and settled in Jerusalem. The Chida, who knew him there in his youth, quotes him in Petach Einayim: “I remember, when I was a child, at the ascent to Jerusalem of the accomplished sage, the pious Rabbi Eliezer Supino”. He had one son and two daughters: Rachel, wife of Rabbi Mahalalel HaKohen, and another daughter married to Rabbi Yaakov Pariente.

He passed away on 3 Kislev 5507 (16 November 1746) and was buried on the Mount of Olives. His epitaph calls him “the accomplished sage, the distinguished judge, the holy chassid, the divine kabbalist”.

Works: the pamphlet on the Shabbat of the bridegroom, burned but found by chance by Shmuel Glick at the Schocken Institute and published by Mossad HaRav Kook; two responsa on chametz that was kept over Pesach; a responsum in Beit Yehuda by Rabbi Yehuda Ayash; and a responsum in the Pachad Yitzchak encyclopedia together with the rabbis of Italy.